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The benefit, when it exists, tends to come from the transient influence those organisms have on immune signaling, gut barrier function, and the existing microbial community while theyre present

Two hundred and seventy-eight patients who responded to open label treatment [defined as meeting the following criteria at weeks 10 and 12: a HAMD-17 total score 9, Clinical Global Impressions of Severity (CGI-S) 2, and not meeting the DSM-IV criteria for MDD] were randomly assigned to continuation of CYMBALTA at the same dosage (N=136) or to placebo (N=142) for 6 months

[PubMed Central ID: PMC11031058]

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