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Loperamide Targeting Altered Bowel Habits This -opioid-receptor agonist, decreasing the contractions of the smooth muscles in the intestinal wall, is specifically used to improve stool frequency and consistency in IBS-D patients (Ford et al., 2018b)

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The results indicated that although both metformin and exercise improved skeletal muscle insulin sensitivity by 55 and 90% respectively the combination resulted in only a 30% enhancement