The advantages of GLP-1 agonists include substantial clinical trial data supporting their efficacy and safety, FDA approval for weight management in certain populations, proven results with many users losing 15-20% or more of body weight, and effects on appetite that make caloric restriction feel natural
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The FDA is evaluating whether regulatory action is necessary after its adverse event reporting system received a growing number of reports of people who used the medications and experienced side effects, such as alopecia (hair loss), aspiration (accidentally breathing in food or liquid), and suicidal thoughts
In the clinical trial, researchers found that many participants crossed below the obesity threshold entirely