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Additionally, IL-6 can be secreted by FLSs and B cells in the RA synovium and has been closely linked to the pathogenesis of the disease [236]
Although administration of V-9302 to decrease glutamine availability increases glucose uptake by cancer cells and immune cells in allograft models, the growth of tumors harboring tumor-infiltrating Tregs, CD8(+) T cells, and NK cells is suppressed 128
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Astragaloside IV ameliorates pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension by restraining the T follicular helper cell response and expanding T follicular regulatory cell response
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