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For weight management , non-pharmacological approaches are strongly recommended: Dietary modification : Working with a registered dietitian to develop a balanced eating plan that maintains adequate nutrition for milk production Physical activity : Gradual return to exercise as appropriate postpartum Behavioural support : Structured weight management programmes that address lifestyle factors Breastfeeding itself supports metabolic health and gradual postpartum weight loss

Carolina Digital Repository (University of North Carolina at Chapel Hill) 2021

The HPA axis, functioning as the neuroendocrine system's master regulator, exhibits intrinsic circadian oscillations in both its basal tone and stress-responsive activity (121).Key HPA effector molecules, particularly glucocorticoids and angiotensin II, modulate BBB permeability in a phase-dependent manner by regulating tight junction proteins (claudin-5, ZO-1) and vascular permeability factors such as VEGF (122125)

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