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No changes were noted in the ileum

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In preclinical neurodegeneration models, Tregs provide dual benefits: Suppression of neuroinflammatory cascades and induction of neurotrophic factor release, including CDNF, via crosstalk with neural substrates [248250]

Davies MJ, Bain SC, Atkin SL, et al

Laboratory Handling and Storage Protocols Lyophilized Powder Storage: Store at -20C to -80C in original sealed vial Protect from light and moisture Desiccated storage environment recommended Stability: 24+ months at -20C Minimize temperature fluctuations Stability Considerations: The disulfide bond between Cys7 and Cys14 is important for biological activity