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Oxidation reactions typically transform the drug into more hydrophilic metabolites by adding or exposing polar functional groups such as hydroxyl (-OH) or amine (-NH 2 ) groups (Table 4-1)

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On the right, the selenium-dependent glutathione peroxidase oxidizes two molecules of GSH back to GSSG in a reaction that converts one molecule of hydrogen peroxide (H 2 O 2 ) into two molecules of water (H 2 O)