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Nagpal R, Wang S, Ahmadi S, Hayes J, Gagliano J, Subashchandrabose S, et al

Over the past 20 years, dozens of preclinical studies (in animals and cells, not humans) have shown potentially promising data suggesting the peptide can fight inflammation and promote protein synthesis and angiogenesisthe fancy scientific term for new blood vessel production

FDA has authorized extended expiration dates for these lots to reflect the 12-month product shelf-life (see Table 1 below), when stored according to the storage conditions detailed in the authorized Fact Sheet for Health Care Providers and the Letter of Authorization for Emergency Use Authorization (EUA) 105 for Paxlovid

Curated data place Melanotan 1 as a full agonist at four subtypes with a clear order-of-magnitude preference for MC1R: pIC 10.0 at MC1R, pKi 8.9 at MC3R, pKi 8.5 to 8.8 at MC4R, pIC 9.0 at MC5R, and no activity at MC2R

doi: 10.1007/s00394-019-01970-1 79