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GSH deficiency as evidenced by a decrease in the GSH/GSSG ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in SARS-CoV-2 infection leading to COVID-19 disease (39, 4353)

Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2

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Oxidative stress and diabetic retinopathy

However, factors like overall health, metabolism, and post-therapy care significantly influence the treatments effectiveness and outcome