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Psychosom Med

(a) DNA methylation DNA methylation is developmentally regulated

The trials used doses ranging from 0.25 mg to 54 mg daily (well above typical protocols) for durations up to 24 weeks

It is unclear how these findings relate to changes in glycemic control in patients with type 2 diabetes

While early and smaller trials showed promising fat-loss effects, the largest Phase IIb trial did not achieve statistical significance in humans for its primary endpoint of weight reduction, which led to the program being discontinued