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The NLRP3 inflammasome is a critical component of the innate immune system responsible for detecting cellular stress and damage signals

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However, molecular signaling of BSO-induced apoptosis is poorly understood, and, recently, it has been demonstrated that in different leukaemia and lymphoma cells, the death receptor-mediated apoptotic pathway, induced by arsenic trioxide plus BSO, is triggered via JNK activation [58]

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