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The key difference is that retatrutide provides triple agonism (GLP-1 + GIP + glucagon) while semaglutide provides only GLP-1 agonism

The subcutaneous route provides an inherent safety margin that makes small air bubbles clinically insignificant

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Also, the lack of a comprehensive analysis of muscle mass across multiple muscle groups and tissues may have limited our ability to fully assess the impact of GLP-1 analogs on muscle health