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These supplements have low bioavailability, which means they are not well-absorbed by the body at low doses

However, those unresponsive to high dose antihistamine therapy used up to quadruple levels may benefit from investigation for underlying autoimmunity, hypovitaminosis D, gastrointestinal dysbiosis and possibly helicobacter infection [113] depending on their clinical evaluation

However, this is not a universal or first-line weight loss solution, and it should never be used without proper medical guidance