semaglutide or metformin for weight loss vs. Semaglutide with Metformin: Safety, Efficacy

This expansion also highlights the limitations of the body mass index (BMI) in defining obesity, as many individuals with normal or mildly elevated BMIs may perceive themselves as needing intervention

In the phase 2 randomised controlled trial (Jastreboff et al., New England Journal of Medicine , 2023), participants receiving higher doses of retatrutide achieved mean weight reductions of up to 17.5% of body weight over 24 weeks, with greater losses reported at 48 weeks

These data confirm that metabolic modulation and weight loss can reduce cardiovascular events even in the absence of hyperglycemia, thereby validating a broader cardiometabolic role

Hormones and diet, but not body weight, control hypothalamic microglial activity

Using expired semaglutide primarily raises concerns about reduced therapeutic efficacy