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The experiment on caffeine intake and the symptoms of adult psychological disorders showed that weekly or higher coffee intake was linked with a considerably decreased risk of having anxiety symptoms when compared to no coffee consumption [141]

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Importantly, the GLP-1R-cholesterol binding sites identified here do not overlap with previously predicted cholesterol consensus motifs (CCM) (22) or Cholesterol Recognition Amino Acid Consensus (CRAC) motifs (52) identified for other GPCRs, confirming the theory that GPCRs lack predictable primary sequence consensus motifs for cholesterol binding (53, 54)

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