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Statistical Analysis The mean and standard deviation (SD) were calculated in tests performed in doublet in 4 donors in duplicate (8 values)

2019;24(2):72-78 Long J

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Half-life & frequency rationale Early intravenous human studies reported a plasma half-life of roughly 15 minutes, with in vitro degradation studies citing a range of about 725 minutes depending on temperature

Cultured rat adipocytes treated with metformin (dose: 4 mM) showed increased UCP2 and ROS levels, and decreased aconitase activity