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During this period, you might notice: Most clinical evidence indicates that noticeable, consistent appetite suppression typically emerges: Beyond dosing considerations, several factors may contribute to unexpected hunger increases in early GLP-1 treatment: Your body has powerful homeostatic mechanisms that can temporarily counteract medication effects: How and when you take semaglutide matters: Even as your body adjusts to semaglutide, maintaining proper nutrition remains essential

Semaglutide may cause diarrhea because the medication can change how food moves through the digestive system and how the body absorbs fatty compounds (lipids) and sugar (glucose)

Prandial insulin often requires significant reduction or discontinuation when adding tirzepatide, as the incretin effect and delayed gastric emptying substantially reduce postprandial glucose excursions

Nagaya, M

Jurkov, M., Danihel, , Polk, & Varga, I