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These mechanisms position PPR as a candidate for managing obesity and type II diabetes

In mice and rats, a once-daily injection of liraglutide, a GLP-1 receptor agonist that has an approximate half-life of 13 h, leads to permanently elevated circulating drug concentrations (32,33) and increased rate of C-cell abnormalities in both mice and rats, with some animals developing C-cell carcinomas, especially among male rats (6)

doi: 10.1530/joe-13-0588 87 MarcocciCBartalenaL

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