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P., Kopach, O., Santana-Varela, S

That's the typical pathway for this demographic: topical exposure first, then discovery of systemic protocols, then a clinical consultation to make sense of the gap between the two

If pain, range of motion, or function has not moved by week 4, the dose or delivery method needs adjusting rather than extending the same protocol blindly

The majority of the studies (see above in red) are preclinical studies in rodents, the vast majority of which have been done by a single research group in Croatia, which has been rinsing and repeating the same approach for decades