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A meta-analysis of seven SURPASS clinical trials in participants with T2DM showed the hazard ratios comparing tirzepatide versus controls of 0.80 (95% CI, 0.57 1.11) for 4-MACE, 0.90 (95% CI, 0.50 1.61) for cardiovascular death, and 0.80 (95% CI, 0.51 1.25) for all-cause mortality (264)

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Excretion Following administration of an oral [ 14 C]sitagliptin dose to healthy subjects, approximately 100% of the administered radioactivity was eliminated in feces (13%) or urine (87%) within one week of dosing

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