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4, 5 L-PAM resistance is an multifactorial phenomenon attributed to reduced drug accumulation, reduced apoptosis, enhanced DNA repair and enhanced glutathione (GSH)/gluathione-s-transferases

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Patients can usually resume their normal daily activities immediately after the procedure

Clinical trials with over 10,000 participants showed cancer incidence rates comparable to control groups, though rodent studies identified thyroid C-cell tumors leading to FDA warnings

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