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PMID:40259493

By affecting both metabolic and neurodegenerative pathways, GLP-1RAs represent a multi-target approach to the treatment of PD, offering hope for improving patient outcomes

1 Dual agonism of GIP and GLP-1 receptors is a promising new approach currently in clinical development for the treatment of diabetes, obesity, and associated complications [1] The incretin effect defines the main physiological role of GIP and GLP-1 GIP and GLP-1 increase insulin secretion following nutrient-induced secretion from the gut (incretin effect): There is a stronger insulin secretion response to oral compared to 'isoglycemic' intravenous glucose administration due to secretion and action of incretin hormones

Balkrishna A, Pokhrel S, Singh H, Joshi M, Mulay VP, Haldar S, Varshney A (2021) Withanone from Withania somnifera attenuates SARS-CoV-2 RBD and Host ACE2 interactions to rescue spike protein induced pathologies in humanized zebrafish model