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semaglutide once-weekly as add-on therapy to metformin in people with type 2 diabetes (SURPASS-2)

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The injection is given into the muscle, typically every few weeks, based on individual needs

The synthesis process carefully manages the incorporation of alpha-aminoisobutyric acid (Aib) at the N-terminus and the D-amino acids (D-2-naphthylalanine and D-phenylalanine), which do not occur in natural proteins but are critical to the peptides final properties

Yoon G, Kim Y, Song J