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Exclusion criteria This review excluded papers that had not fit the scope of the review and those not published in English or for which no English translation was available

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TLR4 can enhance the production of pro-inflammatory cytokines and chemokines, such as IL-6 and IL-17, by binding with exogenous ligands, like peptidoglycan, in FLS and peripheral blood mononuclear (PBMC) from RA patients, and trigger cartilage inflammation and degeneration (135)

It became popular in the injury-recovery world because preclinical studies suggest it may support tissue repair, particularly in tendons, ligaments, and muscle