During a median follow-up of 5.4 (IQR 5.15.9) years, patients with a 1.5 mg/week subcutaneous injection of dulaglutide showed a lower incidence rate of the primary composite outcome including non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular causes ( HR = 0.88, 95% CI 0.790.99, P = 0.026) [62]
doi: 10.1097/PAS.0000000000001195 39 YlamosONavarrete-DechentCMarchettiMARogersTApallaZBahadoranPet al
If your GIP receptors have desensitized alongside your GLP-1 receptors, switching to a pure GLP-1 agonist removes the GIP stimulus entirely, allowing those receptors to recover while you maintain GLP-1 mediated appetite suppression with a different agonist profile
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The coexistence of both diseases not only induced a systemic pro-inflammatory state leading to coronary microvascular endothelial inflammation and resulting in myocardial dysfunction, but also induced a persistent pro-inflammatory state causing cardiac fibrosis that led to myocardial necrosis [7,8,9,10]
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