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S4b) and transfected these constructed vectors into HEK293 cells along with synthetic mature miR-483-3p double-stranded RNA (miR-483-3p mimic, miR-483-3p) or a control miRNA (miR-C) with a scrambled sequence

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Abbreviations L-ca: L-carnitine MSG: Monosodium Glutamate MDA: Malondialdehyde Ca: Calcium P: Phosphorous PCT: Proximal convoluted tubule DCT: Distal convoluted tubule ROS: Reactive oxygen species SOD: Superoxide dismutase BUN: Blood urea nitrogen GPX: Glutathione peroxidase ELISA: Enzyme linked immunosorbent assay APAF1: Apoptotic protease activating factor 1 CAT: Catalase References Quines CB, Rosa SG, Da Rocha JT, Gai BM, Bortolatto CF, Duarte MMM, Nogueira CW

Pregnant or breastfeeding women Individuals with a history of medullary thyroid carcinoma (MTC) Patients with multiple endocrine neoplasia type 2 (MEN2) Children and adolescents Those with significant GI motility disorders (unless cleared by a physician) Possible Side Effects of Cagrilintide Cagrilintide is generally well tolerated, but may cause: Nausea (dose-related) Decreased appetite Mild headache or fatigue GI side effects often resolve with slow dose titration