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Intriguingly, these cells continue to rely on glycolysis for energy production even in the presence of ample oxygen, a phenomenon referred to as the Warburg effect

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The closest relationship with UC is HLA-II genes, in which DR2 and DR9 at the DR Site are considered to be susceptible genes to UC, whereas DR4 is a defensive gene and promotes the expression stage of HLA-DR antigen in the colon mucosal epithelium of UC sufferers (29, 30)