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Prior to the development of these targeted compounds, metabolic and longevity research relied largely on indirect calorie restriction models or broad hormonal modulation

2023;120:e2209184120

This narrative review comprehensively synthesizes current scientific knowledge regarding the role of mitochondrial dysfunction in major CVDs, such as hypertension, coronary artery disease, and heart failure, as well as neurodegenerative and vascular cognitive disorders, including AD and VCI

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