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We also appreciate commenters' concerns regarding the proposed methodology updates and how emphasizing the Safety of Care measure group through the Star Cap and 1-star reduction in turn deemphasizes the influence of the other four measure groups

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The Hospira (Pfizer) label, one of the most common brands, states it plainly: "Bacteriostatic Water for Injection may be used within 28 days of initial entry into the container." So mark the open date on the vial