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Peptide chains clump together into insoluble complexes that cannot be reversed by re-cooling

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In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis

Although the ultimate goal of SCIT and SLIT is to induce immune tolerance, the differences in their drug-assing pathways lead to different initial immune activation sites and follow-up mechanisms