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These compounds block the action of an enzyme, dipeptidyl peptidase-IV, which normally rapidly degrades GLP-1

Plasma levels of active extracellular matrix metalloproteinases 2 and 9 in patients with essential hypertension before and after antihypertensive treatment

RS induces cellular senescence, which hampers cell reproduction and proliferation in response to damage, and senescent cells develop a phenotype characterized by the secretion of factors like interleukins, chemokines, matrix metalloproteases (MMPs), and extracellular matrix (ECM) proteins [15]

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Hilton MP, Zimmermann EF, Hunt WT