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An RCT examining the effects of orlistat 120 mg three times daily in individuals with T2DM on metformin reported a mean weight loss of 4.6% and a HbA1c reduction of 0.61% in the orlistat group over 52 weeks, both significantly higher than those in the placebo group [858]

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This method ensures that the drug is delivered directly into the bloodstream, leading to quicker and more reliable therapeutic outcomes

Oral glutathione has poor bioavailability because stomach acid and gut enzymes break the molecule apart before it reaches the bloodstream