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Cotadutide (MEDI0382) is the most extensively developed dual GLP-1/glucagon receptor agonist, showing significant improvements in glucose control, BW (likely mediated by reduced energy intake rather than increased energy expenditure), hepatic fat, and albuminuria in a small RCT on patients with T2D and overweight or obesity 45,46
Oxidative stress can initiate inflammation by causing cellular damage
Notably, these phenotypes could be recapitulated in wild-type mice that received fecal microbiota transplantation (FMT) of inflammatory depression patients feces, and C
Accumulating evidence indicates that OS not only triggers inflammatory responses but also directly contributes to liver damage in ALD (Louvet and Mathurin, 2015)
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