Of the older therapies, sulphonylureas, insulin and glitazones are all associated with significant weight gain, whereas metformin is associated with slight weight loss
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The results of this study can help to inform strategies to increase utilization of novel medications when appropriate, and to target efforts to ensure patients are receiving medications that have real benefits for them, especially high-risk, vulnerable populations who, owing to inherent biases in medical practice, can be excluded from these therapies, the researchers wrote