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This creates challenges related to desire and sexual attraction, potentially impacting overall sexual function. He adds: Oestrogen is a key sex hormone, so taking GLP-1s might disrupt its balance, which can lead to emotional disturbances
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[2] There is also a converse consideration that responsible modeling should note: a ghrelin-receptor agonist is, among other things, an appetite signal, and GHSR-1a activation has been associated with increased food intake in human work on related peptides
Int J Mol Med 14:207215 Biernacka BA, Koceak P, Owczarek AJ, Choreza P, Puzianowska KM, Markuszewski L, Madej P, Chudek J, Olszanecka GM (2022) SHBG Prediction of insulin resistance and impaired fasting glucose based on Sex Hormone-Binding Globulin (SHBG) levels in polycystic ovary syndrome