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After a 5-hour fast, mice were given water or sitagliptin (Merck Laboratories) by oral gavage at 14 g/mouse (for intestinal-selective inhibition of DPP-4, ref

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These effects are generally temporary, with duration and intensity varying among individuals

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In practice, this means starting on the lowest dose, eating smaller meals with fat spread across the day rather than concentrated in one sitting, and building up gradually

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doi:10.1021/bi0117192

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Healthy gut function supports proper L-cell signalling, which is the foundation of GLP-1 production

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