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Yes, GLP-1 injections including compounded semaglutide and tirzepatide require proper refrigeration between 36F and 46F (2C to 8C) when not in use

194 GLP-1 is expressed in neurons of the brainstem and GLP-1R is present in the hypothalamic regions that regulate energy homeostasis and appetite

Soka Cvetni T, ali A, Benkovi M, Jurina T, Valinger D, Gajdo Kljusuri J, Zeli B, Jurinjak Tuek A (2023) A Systematic review of enzymatic kinetics in microreactors

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