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EIF2, the eIF2 subunit of eIF2, was subsequently activated, leading to the activation of the GCN2-ATF4 signaling pathway [228]

Methods Mice Phox2b-Cre-Tomato mice were obtained by breeding Phox2b-Cre (stock#016223) and Tomato reporter mice (stock# 007909) animals purchased from the Jackson Laboratory (Bar Harbor)

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These losses mostly impact areas of the brain, such as the cerebral cortex and hippocampus, which are also affected in Tg mice that overexpress Glud1