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Statements Author contributions WJ: Writing original draft

However, once your target weight is achieved, maintaining weight loss requires more than just managing your appetite

Additionally, the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity trial demonstrated that semaglutide consistently reduced major cardiovascular event endpoints by approximately 20% compared to placebo over an approximately 3-year follow-up period in patients with overweight or obesity and cardiovascular disease (Table 1), but without diabetes [93]

When it modulates brain signaling, you simply want less food