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It activates melanocortin receptors in the central nervous system, triggering dopamine release and boosting sexual motivation, making it especially useful when low desire is the main concern

Mutations in the MCCC1 gene cause 3-methylcrotonylglycinuria type I, while mutations in the MCCC2 gene cause 3-methylcrotonylglycinuria type II

Given the shared pathophysiological features of many psychiatric conditions, including oxidative stress, impaired synaptic plasticity, and neuronal damage, researchers are exploring GLP1As as innovative treatments beyond current indications

These findings indicate that a long-term safety study with independent validation is required before drawing any conclusions about the safety of MK-677

Author contributions HZ: Conceptualization, Investigation, Writing original draft, Writing review & editing