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Sugiyama C, Yamamoto M, Kotani T, et al

Strength training does not have to be extreme, but it should be consistent and appropriate for the patients age, fitness level, joint health, and medical history

Overall, our integrative analysis not only elucidates a previously unrecognized regulatory axis in lipedema but also provides a mechanistic framework for biomarker discovery and targeted therapy development, aligning with the core translational goals of precision medicine