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[DOI] [PMC free article] [PubMed] [Google Scholar] Yang Y, Kim W, Kim D, Jeong S, Yoo JW, Jung Y (2018) A colon-specific prodrug of metoclopramide ameliorates colitis in an experimental rat model

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In addition, chronic macrophage activation can lead to sustained neuroinflammation, which has been associated with alterations in dopamine and glutamate signaling, further complicating the neurochemical landscape in MDD [160]

The work, which used the protein insulin-like growth factor-1 (IGF-1), showed that an orally delivered, shelf-stable medication grown in lettuce plants could stimulate the growth of bone-building cells and promote bone regeneration