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Important safety considerations include an increased risk of hypoglycemia when used with insulin or sulfonylureas, and a boxed warning about thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2)

According to the evolutionary and sequence diversity, microsomal GSTs have been identified to be the integral membrane proteins and are known as M embrane- A ssociated P roteins in E icosanoid and G lutathione M etabolism (MAPEGs)

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For the extraction of total RNA, tissue samples were pulverized using GenoGrinder (ColeParmer), then homogenized in Tri Reagent (Molecular Research Center or Ambion by Life Technologies) using a MagNa Lyser or TissueLyser II system (Qiagen)

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