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Nuclear factor erythroid 2-related factor 2 (Nrf2) is one of the key transcription factors regulating antioxidant system activity

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Recognizing these symptoms early can be vital in preventing more serious complications, making it essential for individuals, especially those in hot climates or engaging in strenuous activities, to remain vigilant about their hydration levels

H., Cant, C., Wanders, R

More importantly, the orally available RNK06395 ERK5-CHAMP showed promising anti-tumor effects, thus representing a potential ERK5-targeting therapy, since many available ERK5 specific small molecule inhibitors and ERK5 PROTAC are ineffective at reducing cancer cell proliferation [41, 42, 47]