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Furthermore, icariin extracted from Epimedium can also function as a GPER agonist by activating GPER and subsequently increasing the expression of sirtuin 1 (Sirt1), thereby reducing the translocation and release of high-mobility group box 1 (HMGB1) and inhibiting inflammation to improve endothelial function in type 1 diabetic rats [193]

et al, Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine

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Genovese, I., Ilari, A., Assaraf, Y