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Use of carnitine in artificial tears has demonstrated rapid and consistent improvements in signs and symptoms in patients with dry eye [159] suggesting an intrinsic homeostatic role for carnitine in the eye [160]

The canonical nuclear factor kappa-B (NF-B) pathway in microglia is a critical regulator of inflammation and drives the M1 phenotype ( In contrast to pro-inflammatory microglial activation, M2 microglia activation increases anti-inflammatory cytokine production, promoting neuroprotection through tissue repair and debris clearance