semaglutide negative reviews Once-weekly 2.4 mg led to significant decreases in body weight and fat mass over 12 months while preserving lean mass and improved muscle function in adults with obesity. Weight and fat My thoughts after 12 months

There is reasonable concern that the loss of body weight from GLP-1 RAs comes from a reduction in lean mass (muscle) as much as it does from body fat

Yet, studying this side effect continues to gauge its full effects

Data availability Individual participant data collected during the trial, after deidentification, the study protocol, statistical analysis plan and the patient information sheet (consent form) can be shared on request

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Scenario 2: Already Lean, Targeting Stubborn Fat Starting point: 80 kg male, 18% body fat, 14.4 kg fat mass