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Next-generation GLP-1 medications like retatrutide and mazdutide build on the foundation semaglutide established

RELATED: GLP-1 agonists: Uses, common brands, and safety info When it comes to the best weight loss medication for PCOS, a 2023 article published in the journal American Family Physician points to Metformin as a first-line treatment for individuals with PCOS who have metabolic issues such as insulin resistance

This early progress reflects both appetite suppression and reduced overall calorie intake, not metabolic rate changes (which develop over 8-12 weeks)

This is also true of liraglutide and tirzepatide, ONeil said