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The development of obesity is rarely due to a single cause
Cho Y, Jeong S, Kim H, Kang D, Lee J, Kang SB, et al
2.4.6 PI3K/AKT and Sirtuin1 The autophagy-lysosomal pathway is responsible for maintaining the metabolic balance of the ECM by sequestering FN within the cytosol and activating lysosomes for degradation in fibrosis ( SalB can also ameliorate autophagy and upregulate Sirtuin1, which can both lessen renal pathological damage and improve renal insufficiency (Pan et al., 2011
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