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To avoid enzymatic cleavage by DPP-4, the N-terminal penultimate amino acid has been replaced with other amino acids (albiglutide, dulaglutide, and semaglutide) or added with a fatty acid moiety (liraglutide and semaglutide), so that albumin binds and shields the enzymatic attack site
Cold plasma treatment offers several advantages over traditional methods
In doing so the molecule is constantly docking and undocking and lengthening the drugs action
Patients typically tolerate it very well, especially when paired with physician oversight, ongoing monitoring, and personalized dosing
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